Maximum Tolerated Dose The maximum tolerated dose (MTD) is the highest daily dose of a substance that does
not cause overt toxicity typically in a ninety-day study in laboratory mice or rats.
This dose is then used for longer-term safety assessment in the same species, usually
lasting two years or a lifetime. The rationale for using the MTD is to maximize the
likelihood of detecting any chronic disease effects of a substance, including cancer.
Using higher doses also increases the statistical likelihood of detecting the intrinsic
hazards of substances. Interested investigators should contact Mgene Biosciences for additional information on sample preparation, storing and shipping as well as any pricing issues at info@mgenebiosciences.com
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