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Chronic Toxicity
Chronic toxicity studies provide a thorough examination of the dose effect of a given
substance on homeostasis, bodily function, induced diseases, and the effect on lifespan.
Chronic toxicity studies provide the bulk of the preclinical information used for assessing
safety and risk. The study is conducted in multiple species, in both sexes, and for a
duration that approaches the lifespan of the animal. These are very large and complex
studies that necessitate a great deal of day-to-day management. There are multiple
intermediate clinical evaluations, including daily observations, weekly food and water
consumption, and body weight determinations. At the termination of the study, or at
times of interim sacrifices, all animals are necropsied.
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