ADME Studies
A-Absorption
D-Distribution
M-Metabolism
E-Excretion
Absorption:
Before a compound can exert a pharmacological effect in tissues, it has to be taken in to the bloodstream. Uptake into the target organs or cells needs to be ensured, too. Absorption critically determines the compound's bio-availability.
Distribution:
The compound needs to be carried to its effector site, most often via the bloodstream. From there, the compound may distribute into tissues and organs, usually to differing extents.
Metabolism:
Compounds begin to be broken down as soon as they enter the body. The majority of small-molecule drug metabolism is carried out in the liver by redox enzymes, termed cytochrome P450 enzymes. As metabolism occurs, the initial (parent) compound is converted to new compounds called metabolites. When metabolites are pharmacologically inert, metabolism deactivates the administered dose of parent drug and this usually reduces the effects on the body. Metabolites may also be pharmacologically active, sometimes more so than the parent drug.
Excretion:
Compounds and their metabolites need to be removed from the body via excretion, usually through the kidneys (urine) or in the feces. Unless excretion is complete, accumulation of foreign substances can adversely affect normal metabolism.
Interested investigators should contact Mgene Biosciences for additional information on sample preparation, storing and shipping as well as any pricing issues at info@mgenebiosciences.com
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